Human BMF activation kit by CRISPRa

CAT#: GA114021

BMF CRISPRa kit - CRISPR gene activation of human Bcl2 modifying factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BMF
• Locus ID: 90427
• Kit Components:

  GA114021G1, BMF gRNA vector 1 in pCas-Guide-CRISPRa

  GA114021G2, BMF gRNA vector 2 in pCas-Guide-CRISPRa

  GA114021G3, BMF gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003940, NM_001003942, NM_001003943, NM_033503, N41452
• Synonyms: FLJ00065
• Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]