Human UBXD5 (UBXN11) activation kit by CRISPRa

CAT#: GA114124

UBXN11 CRISPRa kit - CRISPR gene activation of human UBX domain protein 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBXN11
• Locus ID: 91544
• Kit Components:

  GA114124G1, UBXN11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114124G2, UBXN11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114124G3, UBXN11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077262, NM_145345, NM_145346, NM_183008
• Synonyms: COA-1; PP2243; SOC; SOCI; UBXD5
• Summary: This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]