Human SYT12 activation kit by CRISPRa

CAT#: GA114141

SYT12 CRISPRa kit - CRISPR gene activation of human synaptotagmin 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SYT12
• Locus ID: 91683
• Kit Components:

  GA114141G1, SYT12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114141G2, SYT12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114141G3, SYT12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001177880, NM_001318773, NM_001318775, NM_177963
• Synonyms: SYT11; sytXII
• Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]