Human LYRIC (MTDH) activation kit by CRISPRa

CAT#: GA114185

MTDH CRISPRa kit - CRISPR gene activation of human metadherin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTDH
• Locus ID: 92140
• Kit Components:

  GA114185G1, MTDH gRNA vector 1 in pCas-Guide-CRISPRa

  GA114185G2, MTDH gRNA vector 2 in pCas-Guide-CRISPRa

  GA114185G3, MTDH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_178812, NM_001363139, NM_001363136, NM_001363137, NM_001363138
• Synonyms: 3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3
• Summary: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. [UniProtKB/Swiss-Prot Function]