Human TIFA activation kit by CRISPRa

CAT#: GA114228

TIFA CRISPRa kit - CRISPR gene activation of human TRAF interacting protein with forkhead associated domain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIFA
• Locus ID: 92610
• Kit Components:

  GA114228G1, TIFA gRNA vector 1 in pCas-Guide-CRISPRa

  GA114228G2, TIFA gRNA vector 2 in pCas-Guide-CRISPRa

  GA114228G3, TIFA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052864
• Synonyms: T2BP; T6BP; TIFAA
• Summary: This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]