Human MARCH9 activation kit by CRISPRa

CAT#: GA114254

MARCH9 CRISPRa kit - CRISPR gene activation of human membrane associated ring-CH-type finger 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARCH9
• Locus ID: 92979
• Kit Components:

  GA114254G1, MARCH9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114254G2, MARCH9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114254G3, MARCH9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_138396
• Synonyms: MARCH-IX; RNF179
• Summary: MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]). [supplied by OMIM, Apr 2010]