Human FBXO44 activation kit by CRISPRa

CAT#: GA114293

FBXO44 CRISPRa kit - CRISPR gene activation of human F-box protein 44

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBXO44
• Locus ID: 93611
• Kit Components:

  GA114293G1, FBXO44 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114293G2, FBXO44 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114293G3, FBXO44 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014765, NM_001304790, NM_001304791, NM_001330355, NM_033182, NM_183412, NM_183413, NR_130909
• Synonyms: FBG3; FBX6A; FBX30; Fbx44; Fbxo6a
• Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]