Human Epithelial Stromal Interaction 1 (EPSTI1) activation kit by CRISPRa

CAT#: GA114342

EPSTI1 CRISPRa kit - CRISPR gene activation of human epithelial stromal interaction 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EPSTI1
• Locus ID: 94240
• Kit Components:

  GA114342G1, EPSTI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114342G2, EPSTI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114342G3, EPSTI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001002264, NM_033255, NM_001330543, NM_001331228
• Synonyms: BRESI1
• Summary: The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016]