Human EGLN2 activation kit by CRISPRa

CAT#: GA114350

EGLN2 CRISPRa kit - CRISPR gene activation of human egl-9 family hypoxia inducible factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EGLN2
• Locus ID: 112398
• Kit Components:

  GA114350G1, EGLN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114350G2, EGLN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114350G3, EGLN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017555, NM_053046, NM_080732
• Synonyms: DKFZp434E026; EIT6; HIFPH1; PHD1
• Summary: The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]