Human Urocortin 3 (UCN3) activation kit by CRISPRa

CAT#: GA114429

UCN3 CRISPRa kit - CRISPR gene activation of human urocortin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UCN3
• Locus ID: 114131
• Kit Components:

  GA114429G1, UCN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114429G2, UCN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114429G3, UCN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_053049
• Synonyms: SCP; SPC; UCNIII
• Summary: This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]