Human SORCS1 activation kit by CRISPRa

CAT#: GA114468

SORCS1 CRISPRa kit - CRISPR gene activation of human sortilin related VPS10 domain containing receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SORCS1
• Locus ID: 114815
• Kit Components:

  GA114468G1, SORCS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114468G2, SORCS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114468G3, SORCS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013031, NM_001206569, NM_001206570, NM_001206571, NM_001206572, NM_052918
• Synonyms: hSorCS
• Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]