Human Porimin (TMEM123) activation kit by CRISPRa

CAT#: GA114494

TMEM123 CRISPRa kit - CRISPR gene activation of human transmembrane protein 123

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMEM123
• Locus ID: 114908
• Kit Components:

  GA114494G1, TMEM123 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114494G2, TMEM123 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114494G3, TMEM123 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052932
• Synonyms: KCT3; PORIMIN; PORMIN
• Summary: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]