Human FCRL3 activation kit by CRISPRa

CAT#: GA114522

FCRL3 CRISPRa kit - CRISPR gene activation of human Fc receptor like 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FCRL3
• Locus ID: 115352
• Kit Components:

  GA114522G1, FCRL3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114522G2, FCRL3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114522G3, FCRL3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024667, NM_001320333, NM_052939, NR_135214, NR_135215, NR_135216, NR_135217
• Synonyms: Fc receptor-like 3; Fc receptor homolog 3; FCRH3; FCRH3, IFGP3, IRTA3, SPAP2; IFGP3; immunoglobulin superfamily receptor translocation associated protein 3; IRTA3; SH2 domain-containing phosphatase anchor protein 2; SPAP2
• Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]