Human NIRF (UHRF2) activation kit by CRISPRa

CAT#: GA114528

UHRF2 CRISPRa kit - CRISPR gene activation of human ubiquitin like with PHD and ring finger domains 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UHRF2
• Locus ID: 115426
• Kit Components:

  GA114528G1, UHRF2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114528G2, UHRF2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114528G3, UHRF2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152306, NM_152896, NR_046386
• Synonyms: NIRF, URF2, RNF107, MGC33463, DKFZp434B0920, DKFZp686G0837, RP11-472F14.2
• Summary: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]