Human BAFF Receptor (TNFRSF13C) activation kit by CRISPRa

CAT#: GA114535

TNFRSF13C CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 13C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF13C
• Locus ID: 115650
• Kit Components:

  GA114535G1, TNFRSF13C gRNA vector 1 in pCas-Guide-CRISPRa

  GA114535G2, TNFRSF13C gRNA vector 2 in pCas-Guide-CRISPRa

  GA114535G3, TNFRSF13C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052945
• Synonyms: BAFF-R; BAFFR; BROMIX; CD268; CVID4; prolixin
• Summary: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]