Human NOSTRIN activation kit by CRISPRa

CAT#: GA114537

NOSTRIN CRISPRa kit - CRISPR gene activation of human nitric oxide synthase trafficking

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NOSTRIN
• Locus ID: 115677
• Kit Components:

  GA114537G1, NOSTRIN gRNA vector 1 in pCas-Guide-CRISPRa

  GA114537G2, NOSTRIN gRNA vector 2 in pCas-Guide-CRISPRa

  GA114537G3, NOSTRIN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039724, NM_001171631, NM_001171632, NM_052946
• Synonyms: DaIP2
• Summary: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production. [supplied by OMIM, Apr 2004]