Human TOP1MT activation kit by CRISPRa

CAT#: GA114595

TOP1MT CRISPRa kit - CRISPR gene activation of human DNA topoisomerase I mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TOP1MT
• Locus ID: 116447
• Kit Components:

  GA114595G1, TOP1MT gRNA vector 1 in pCas-Guide-CRISPRa

  GA114595G2, TOP1MT gRNA vector 2 in pCas-Guide-CRISPRa

  GA114595G3, TOP1MT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001258446, NM_001258447, NM_052963
• Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]