Human Apolipoprotein A V (APOA5) activation kit by CRISPRa

CAT#: GA114602

APOA5 CRISPRa kit - CRISPR gene activation of human apolipoprotein A5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APOA5
• Locus ID: 116519
• Kit Components:

  GA114602G1, APOA5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114602G2, APOA5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114602G3, APOA5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166598, NM_052968
• Synonyms: APOAV; RAP3
• Summary: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]