Human Dermcidin (DCD) activation kit by CRISPRa

CAT#: GA114631

DCD CRISPRa kit - CRISPR gene activation of human dermcidin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DCD
• Locus ID: 117159
• Kit Components:

  GA114631G1, DCD gRNA vector 1 in pCas-Guide-CRISPRa

  GA114631G2, DCD gRNA vector 2 in pCas-Guide-CRISPRa

  GA114631G3, DCD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300854, NM_053283
• Synonyms: AIDD; DCD-1; DSEP; HCAP; PIF
• Summary: This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]