Human RAB3IP activation kit by CRISPRa

CAT#: GA114633

RAB3IP CRISPRa kit - CRISPR gene activation of human RAB3A interacting protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAB3IP
• Locus ID: 117177
• Kit Components:

  GA114633G1, RAB3IP gRNA vector 1 in pCas-Guide-CRISPRa

  GA114633G2, RAB3IP gRNA vector 2 in pCas-Guide-CRISPRa

  GA114633G3, RAB3IP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024647, NM_001278402, NM_022456, NM_175623, NM_175624, NM_175625, NM_175626, NM_175627, NR_103519, NR_103520
• Synonyms: RABIN3; RABIN8
• Summary: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. [UniProtKB/Swiss-Prot Function]