Human TWIST2 activation kit by CRISPRa

CAT#: GA114649

TWIST2 CRISPRa kit - CRISPR gene activation of human twist family bHLH transcription factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TWIST2
• Locus ID: 117581
• Kit Components:

  GA114649G1, TWIST2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114649G2, TWIST2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114649G3, TWIST2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271893, NM_057179
• Synonyms: AMS; BBRSAY; bHLHa39; DERMO1; FFDD3; SETLSS
• Summary: The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]