Human LRRK2 activation kit by CRISPRa

CAT#: GA114729

LRRK2 CRISPRa kit - CRISPR gene activation of human leucine rich repeat kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LRRK2
• Locus ID: 120892
• Kit Components:

  GA114729G1, LRRK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114729G2, LRRK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114729G3, LRRK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_198578
• Synonyms: AURA17; DARDARIN; PARK8; RIPK7; ROCO2
• Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]