Human FGD4 activation kit by CRISPRa

CAT#: GA114753

FGD4 CRISPRa kit - CRISPR gene activation of human FYVE, RhoGEF and PH domain containing 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGD4
• Locus ID: 121512
• Kit Components:

  GA114753G1, FGD4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114753G2, FGD4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114753G3, FGD4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304480, NM_001304481, NM_001304483, NM_001304484, NM_001330373, NM_001330374, NM_139241, NM_001370297, NM_001370298
• Synonyms: CMT4H; FRABP; ZFYVE6
• Summary: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]