Human PPIL5 (LRR1) activation kit by CRISPRa

CAT#: GA114786

LRR1 CRISPRa kit - CRISPR gene activation of human leucine rich repeat protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LRR1
• Locus ID: 122769
• Kit Components:

  GA114786G1, LRR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114786G2, LRR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114786G3, LRR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152329, NM_203466, NM_203467, NR_037792, NR_037793
• Synonyms: 4-1BBLRR; LRR-1; PPIL5
• Summary: The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]