Human LEO1 activation kit by CRISPRa

CAT#: GA114802

LEO1 CRISPRa kit - CRISPR gene activation of human LEO1 homolog, Paf1/RNA polymerase II complex component

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LEO1
• Locus ID: 123169
• Kit Components:

  GA114802G1, LEO1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114802G2, LEO1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114802G3, LEO1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286430, NM_001323903, NM_001323904, NM_138792
• Synonyms: RDL
• Summary: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]). [supplied by OMIM, Mar 2008]