Human KIAA1970 (EARS2) activation kit by CRISPRa

CAT#: GA114841

EARS2 CRISPRa kit - CRISPR gene activation of human glutamyl-tRNA synthetase 2, mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EARS2
• Locus ID: 124454
• Kit Components:

  GA114841G1, EARS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114841G2, EARS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114841G3, EARS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083614, NM_001308211, NM_133451, NR_003501
• Synonyms: COXPD12; gluRS; MSE1
• Summary: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]