Human OSCAR activation kit by CRISPRa

CAT#: GA114909

OSCAR CRISPRa kit - CRISPR gene activation of human osteoclast associated Ig-like receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OSCAR
• Locus ID: 126014
• Kit Components:

  GA114909G1, OSCAR gRNA vector 1 in pCas-Guide-CRISPRa

  GA114909G2, OSCAR gRNA vector 2 in pCas-Guide-CRISPRa

  GA114909G3, OSCAR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282349, NM_001282350, NM_130771, NM_133168, NM_133169, NM_206817, NM_206818
• Synonyms: PIgR-3; PIGR3
• Summary: Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]