Human C22orf25 (TANGO2) activation kit by CRISPRa

CAT#: GA115072

TANGO2 CRISPRa kit - CRISPR gene activation of human transport and golgi organization 2 homolog

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TANGO2
• Locus ID: 128989
• Kit Components:

  GA115072G1, TANGO2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115072G2, TANGO2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115072G3, TANGO2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001283106, NM_001283116, NM_001283129, NM_001283148, NM_001283154, NM_001283179, NM_001283186, NM_001283199, NM_001283215, NM_001283235, NM_001283248, NM_001322141, NM_001322142, NM_001322143, NM_001322144, NM_001322145, NM_001322146, NM_001322147, NM_001322148, NM_001322149, NM_001322150, NM_001322153, NM_001322155, NM_001322160, NM_001322163, NM_001322166, NM_001322167, NM_001322169, NM_001322171, NM_001322172, NM_001322173, NM_001322174, NM_001322175, NM_152906, NR_104274, NR_104275, NR_136206, NR_136211, NR_136212
• Synonyms: C22orf25; MECRCN
• Summary: This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]