Human IL31RA activation kit by CRISPRa

CAT#: GA115197

IL31RA CRISPRa kit - CRISPR gene activation of human interleukin 31 receptor A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL31RA
• Locus ID: 133396
• Kit Components:

  GA115197G1, IL31RA gRNA vector 1 in pCas-Guide-CRISPRa

  GA115197G2, IL31RA gRNA vector 2 in pCas-Guide-CRISPRa

  GA115197G3, IL31RA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242636, NM_001242637, NM_001242638, NM_001242639, NM_001297570, NM_001297572, NM_139017
• Synonyms: CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R; IL-31RA; PLCA2; PRO21384
• Summary: The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]