Human PGC1 beta (PPARGC1B) activation kit by CRISPRa

CAT#: GA115201

PPARGC1B CRISPRa kit - CRISPR gene activation of human PPARG coactivator 1 beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPARGC1B
• Locus ID: 133522
• Kit Components:

  GA115201G1, PPARGC1B gRNA vector 1 in pCas-Guide-CRISPRa

  GA115201G2, PPARGC1B gRNA vector 2 in pCas-Guide-CRISPRa

  GA115201G3, PPARGC1B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172698, NM_001172699, NM_133263
• Synonyms: ERRL1; PERC; PGC-1(beta); PGC1B
• Summary: The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]