Human RIPPLY2 activation kit by CRISPRa

CAT#: GA115235

RIPPLY2 CRISPRa kit - CRISPR gene activation of human ripply transcriptional repressor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RIPPLY2
• Locus ID: 134701
• Kit Components:

  GA115235G1, RIPPLY2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115235G2, RIPPLY2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115235G3, RIPPLY2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001009994, NR_103525
• Synonyms: C6orf159; dJ237I15.1; SCDO6
• Summary: This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]