Human Tomosyn (STXBP5) activation kit by CRISPRa

CAT#: GA115240

STXBP5 CRISPRa kit - CRISPR gene activation of human syntaxin binding protein 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STXBP5
• Locus ID: 134957
• Kit Components:

  GA115240G1, STXBP5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115240G2, STXBP5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115240G3, STXBP5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127715, NM_139244
• Synonyms: LGL3; LLGL3; Nbla04300
• Summary: Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]