Human GAB3 activation kit by CRISPRa

CAT#: GA115348

GAB3 CRISPRa kit - CRISPR gene activation of human GRB2 associated binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GAB3
• Locus ID: 139716
• Kit Components:

  GA115348G1, GAB3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115348G2, GAB3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115348G3, GAB3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081573, NM_001282283, NM_080612, NR_104114
• Synonyms: DOS/Gab family member 3; Gab3 protein; Gab3 scaffolding protein; GRB2-associated binding protein 3; OTTHUMP00000026055
• Summary: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]