Human DUSP19 activation kit by CRISPRa

CAT#: GA115437

DUSP19 CRISPRa kit - CRISPR gene activation of human dual specificity phosphatase 19

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DUSP19
• Locus ID: 142679
• Kit Components:

  GA115437G1, DUSP19 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115437G2, DUSP19 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115437G3, DUSP19 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142314, NM_001321519, NM_080876, NR_135688
• Synonyms: DUSP17; LMWDSP3; SKRP1; TS-DSP1
• Summary: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]). [supplied by OMIM, Dec 2009]