Human FRMPD2 activation kit by CRISPRa

CAT#: GA115449

FRMPD2 CRISPRa kit - CRISPR gene activation of human FERM and PDZ domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FRMPD2
• Locus ID: 143162
• Kit Components:

  GA115449G1, FRMPD2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115449G2, FRMPD2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115449G3, FRMPD2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017929, NM_001018071, NM_001042512, NM_001318191, NM_152428, NR_033178
• Synonyms: FERM and PDZ domain containing 2; MGC35285; MGC87776; MGC87777; MGC90186; PDZD5C; PDZ domain containing 5C; PDZK5C
• Summary: This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]