Human SESN3 activation kit by CRISPRa

CAT#: GA115469

SESN3 CRISPRa kit - CRISPR gene activation of human sestrin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SESN3
• Locus ID: 143686
• Kit Components:

  GA115469G1, SESN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115469G2, SESN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115469G3, SESN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271594, NM_144665
• Synonyms: SEST3
• Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]