Human C13orf31 (LACC1) activation kit by CRISPRa

CAT#: GA115509

LACC1 CRISPRa kit - CRISPR gene activation of human laccase domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LACC1
• Locus ID: 144811
• Kit Components:

  GA115509G1, LACC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115509G2, LACC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115509G3, LACC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128303, NM_153218, NM_001350638, NM_001350639, NM_001350640, NM_001350641, NM_001350642, NM_001350643, NM_001350644, NM_001350645, NM_001350646, NM_001350647, NM_001350648
• Synonyms: C13orf31; FAMIN
• Summary: This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]