Human OTOA activation kit by CRISPRa

CAT#: GA115546

OTOA CRISPRa kit - CRISPR gene activation of human otoancorin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OTOA
• Locus ID: 146183
• Kit Components:

  GA115546G1, OTOA gRNA vector 1 in pCas-Guide-CRISPRa

  GA115546G2, OTOA gRNA vector 2 in pCas-Guide-CRISPRa

  GA115546G3, OTOA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161683, NM_144672, NM_170664
• Synonyms: CT108; DFNB22
• Summary: The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]