Human BEAN1 activation kit by CRISPRa

CAT#: GA115552

BEAN1 CRISPRa kit - CRISPR gene activation of human brain expressed associated with NEDD4 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BEAN1
• Locus ID: 146227
• Kit Components:

  GA115552G1, BEAN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115552G2, BEAN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115552G3, BEAN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136106, NM_001178020, NM_001197224, NM_001197225
• Synonyms: BEAN; SCA31
• Summary: The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]