Human EVER2 (TMC8) activation kit by CRISPRa

CAT#: GA115598

TMC8 CRISPRa kit - CRISPR gene activation of human transmembrane channel like 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMC8
• Locus ID: 147138
• Kit Components:

  GA115598G1, TMC8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115598G2, TMC8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115598G3, TMC8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152468
• Synonyms: EV2; EVER2; EVIN2
• Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]