Human Phospholipase A2 (PLB1) activation kit by CRISPRa

CAT#: GA115776

PLB1 CRISPRa kit - CRISPR gene activation of human phospholipase B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLB1
• Locus ID: 151056
• Kit Components:

  GA115776G1, PLB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115776G2, PLB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115776G3, PLB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001170585, NM_153021, NR_138141
• Synonyms: PLB; PLB/LIP
• Summary: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]