Human CCDC50 activation kit by CRISPRa

CAT#: GA115824

CCDC50 CRISPRa kit - CRISPR gene activation of human coiled-coil domain containing 50

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCDC50
• Locus ID: 152137
• Kit Components:

  GA115824G1, CCDC50 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115824G2, CCDC50 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115824G3, CCDC50 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_174908, NM_178335
• Synonyms: C3orf6; DFNA44; YMER
• Summary: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]