Human ATP6V0E2 activation kit by CRISPRa

CAT#: GA115910

ATP6V0E2 CRISPRa kit - CRISPR gene activation of human ATPase H+ transporting V0 subunit e2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP6V0E2
• Locus ID: 155066
• Kit Components:

  GA115910G1, ATP6V0E2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115910G2, ATP6V0E2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115910G3, ATP6V0E2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001100592, NM_001289990, NM_145230, NR_110612, NM_001367788, NM_001367789, NM_001367791, NM_001367792, NM_001367793, NM_001367794, NM_001367796, NM_001367797, NM_001367795
• Synonyms: ATP6V0E2L; C7orf32
• Summary: Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]). [supplied by OMIM, Mar 2008]