Human EXDL1 (EXD1) activation kit by CRISPRa

CAT#: GA116035

EXD1 CRISPRa kit - CRISPR gene activation of human exonuclease 3'-5' domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EXD1
• Locus ID: 161829
• Kit Components:

  GA116035G1, EXD1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116035G2, EXD1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116035G3, EXD1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286441, NM_152596
• Synonyms: EXDL1
• Summary: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease. [UniProtKB/Swiss-Prot Function]