Human CITED4 activation kit by CRISPRa

CAT#: GA116095

CITED4 CRISPRa kit - CRISPR gene activation of human Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CITED4
• Locus ID: 163732
• Kit Components:

  GA116095G1, CITED4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116095G2, CITED4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116095G3, CITED4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_133467
• Synonyms: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; OTTHUMP00000009206; transcriptional co-activator 4
• Summary: The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]