Human ZNF384 activation kit by CRISPRa

CAT#: GA116233

ZNF384 CRISPRa kit - CRISPR gene activation of human zinc finger protein 384

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZNF384
• Locus ID: 171017
• Kit Components:

  GA116233G1, ZNF384 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116233G2, ZNF384 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116233G3, ZNF384 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039916, NM_001039917, NM_001039918, NM_001039919, NM_001039920, NM_001135734, NM_133476
• Synonyms: CAGH1; CAGH1A; CIZ; ERDA2; FLJ59043; NMP4; NP; TNRC1
• Summary: This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]