Human ADCY4 activation kit by CRISPRa

CAT#: GA116288

ADCY4 CRISPRa kit - CRISPR gene activation of human adenylate cyclase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADCY4
• Locus ID: 196883
• Kit Components:

  GA116288G1, ADCY4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116288G2, ADCY4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116288G3, ADCY4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198568, NM_001198592, NM_139247
• Synonyms: AC4
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]