Human NLRP7 activation kit by CRISPRa

CAT#: GA116312

NLRP7 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NLRP7
• Locus ID: 199713
• Kit Components:

  GA116312G1, NLRP7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116312G2, NLRP7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116312G3, NLRP7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127255, NM_139176, NM_206828
• Synonyms: CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
• Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]