Human TIGIT activation kit by CRISPRa

CAT#: GA116403

TIGIT CRISPRa kit - CRISPR gene activation of human T cell immunoreceptor with Ig and ITIM domains

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIGIT
• Locus ID: 201633
• Kit Components:

  GA116403G1, TIGIT gRNA vector 1 in pCas-Guide-CRISPRa

  GA116403G2, TIGIT gRNA vector 2 in pCas-Guide-CRISPRa

  GA116403G3, TIGIT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_173799
• Synonyms: VSIG9; VSTM3; WUCAM
• Summary: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [provided by RefSeq, Sep 2009]