Human USP12 activation kit by CRISPRa

CAT#: GA116474

USP12 CRISPRa kit - CRISPR gene activation of human ubiquitin specific peptidase 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: USP12
• Locus ID: 219333
• Kit Components:

  GA116474G1, USP12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116474G2, USP12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116474G3, USP12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_182488
• Synonyms: UBH1; USP12L1
• Summary: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). [UniProtKB/Swiss-Prot Function]